| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to novel additive salt of pyperidin-4-ylamide of 4-(2,6-dichlorbenzoylamino-1H-pyrazole-3-carboxylic acid and acid, where said salt is obtained with application of acid, selected from metasulfonic acid and acidic acid and their mixtures. Invention also relates to methods of obtaining additive salt of pyperidin-4-ylamide of 4-(2,6-dichlorbenzoylamino)-1H-pyrazole-3-carboxylic acid and acid with acid, to method of obtaining of pyperidin4-ylamide of 4-(2,6-dichlorbenzoylamino-1H-pyrazole-3-carboxylic acid, to method of obtaining intermediate compound of formula (XIII), to novel intermediate compound of formula (XII), to method of obtaining pyperidin-4-ylamide of 4-(2,6-dichlorbenzoylamino)-1H-pyrazole-3-carboxylic acid, to method of prevention and treatment of disease or disease state mediated by cyclin-dependent kinase or glycogen synthase-3 kinase, to method of state alleviation or reduction of manifestations of disease or disease state, mediated by cyclin-dependent kinase or glycogen synthase-3 kinase, to method of treatment of disease or state, which includes abnormal cell growth or resulting from abnormal cell growth in mammal, to method of alleviation of state or reduction of manifestations of disease or state, which includes abnormal cell growth or resulting from abnormal cell growth in mammal, to method of treatment of disease or state, which includes abnormal cell growth or resulting from abnormal cell growth in mammal, to application of additive salt with acid of pyperidin-4-ylamide of 4-(2,6-dichlorbenzoylamino)-1H-pyrazole-3-carboxylic acid, to pyperidin-4-ylamide of 4-(2,6-dichlorbenzoylamino)-1H-pyrazole-3-carboxylic acid, to method of treating B-cell lymphoma, diffuse B-large cell lymphoma or chronic lymphocytic leukemia, to method of diagnostics and treatment of disease or disease state, mediated by cyclin-dependent kinase, to application of additive salt with acid of pyperidin-4-ylamide of 4-(2,6-dichlorbenzoylamino)-1H-pyrazole-3-carboxylic acid, to method of inhibiting tumour growth in mammal, as well as to method of inhibiting tumour cell growth. ^ EFFECT: obtaining novel biologically active compounds, which possess anti-proliferative activity. ^ 75 cl, 19 ex, 5 dwg |
