发明名称 |
HYDROPHOBIC MODIFIED PRES-DERIVED PEPTIDES OF HEPATITIS B VIRUS (HBV) AND THEIR USE AS HBV AND HDV ENTRY INHIBITORS |
摘要 |
The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are derived from a HBV preS consensus sequence and are N-terminal preferably acylated and optional C-terminal modified. These hydrophobic modified preS-derived peptides of HBV are very effective HBV entry inhibitors as well as HDV entry inhibitors and are, thus, suitable for the inhibition of HBV and/or HDV infection, prevention of primary HBV and/or HDV infection as well as treatment of (chronic) hepatitis B and/or D. The present invention further relates to pharmaceutical and vaccine compositions comprising these hydrophobic modified preS-derived peptides of HBV.
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申请公布号 |
US2011020397(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20090863663 |
申请日期 |
2009.01.26 |
申请人 |
UNIVERSITATSKINIKUM HEIDELBERG |
发明人 |
MIER WALTER;URBAN STEPHAN |
分类号 |
A61K39/29;A61P31/20;C07K7/08;C07K14/02 |
主分类号 |
A61K39/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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