发明名称 |
NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE |
摘要 |
Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).
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申请公布号 |
US2011021532(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20090934100 |
申请日期 |
2009.04.21 |
申请人 |
MERCK FROSST CANADA LTD. |
发明人 |
POWELL DAVID;LEBRUN MARIE-EVE;BHAT SATHESH;RAMTOHUL YEEMAN K. |
分类号 |
A61K31/501;A61K31/4184;A61K31/437;A61K31/4439;A61K31/506;A61P1/16;A61P3/00;A61P3/04;A61P3/10;A61P9/00;A61P9/10;C07D235/18;C07D401/02;C07D403/04;C07D471/02 |
主分类号 |
A61K31/501 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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