PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE NIPECOTAMIDE

摘要

Disclosed is a process for producing optically active nipecotamide, which comprises the steps of: reacting nipecotamide with optically active lactic acid in a solvent to prepare a diastereomer salt mixture and causing one of diastereomer salts contained in the diastereomer salt mixture to precipitate; collecting the precipitated diastereomer salt; and treating the collected diastereomer salt with a base to cause optically active nipecotamide to release. The process enables the advantageous production of optically active nipecotamide on a commercial scale.