发明名称 |
Method and quantification assay for determining c-kit/SCF/pAKT status |
摘要 |
The present invention relates to a method for predicting the response to administration of a chemotherapeutic or biological therapeutic agent consisting of tyrosine kinase inhibitors to an individual, comprising detecting the amount of one or a plurality of biological markers in a tissue or cell sample originating from the individual, wherein the biological markers are cellular components to the c-kit pathway and comparing the amount of the one or the plurality of biological markers detected in subpart (a) with the amount detected in one or a plurality of control tissue or cell samples, wherein a response to the administration of a chemotherapeutic or biological therapeutic agent to an individual is predicted based on the comparison of the amount of the one or the plurality of biological markers from one or a plurality of control tissue or cell samples. |
申请公布号 |
EP2277991(A1) |
申请公布日期 |
2011.01.26 |
申请号 |
EP20100011262 |
申请日期 |
2002.08.21 |
申请人 |
VENTANA MEDICAL SYSTEMS, INC. |
发明人 |
BACUS, SARAH S. |
分类号 |
C12N5/00;A61K31/00;C12N5/08;C12Q1/02;C12Q1/68;G01N1/30;G01N33/15;G01N33/48;G01N33/50;G01N33/536;G01N33/543;G01N33/555;G01N33/566;G01N33/567;G01N33/574 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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