发明名称 |
Epitope cluster from Melan-A/MART-1 for the induction of anti-tumor immunogenicity |
摘要 |
<p>Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.</p> |
申请公布号 |
EP2278023(A1) |
申请公布日期 |
2011.01.26 |
申请号 |
EP20100178756 |
申请日期 |
2001.04.27 |
申请人 |
MANNKIND CORPORATION |
发明人 |
SIMARD, JOHN, J.,L;DIAMOND, DAVID, C.;LEI, XIANG-DONG |
分类号 |
C12N15/09;C12Q1/37;A61K39/00;A61K39/002;A61K39/008;A61K39/015;A61K39/02;A61K39/04;A61K39/10;A61K39/112;A61K39/118;A61K39/12;A61K39/13;A61K39/20;A61K39/21;A61K39/23;A61K39/235;A61K39/245;A61K39/29;A61P31/00;A61P33/00;A61P35/00;C07K14/00;C07K16/18;C12N5/10;C12Q1/68;G01N33/569 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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