N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE PROPIONATE, METHOD OF PREPARING THE SAME, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND COMBINED FORMULATION INCLUDING THE SAME

摘要

PURPOSE: A metformin propionate is provided to ensure an excellent pharmacological effect as compared with metformin hydrochloride and to achieve a therapeutic purpose by administering an amount less than metformin hydrochloride. CONSTITUTION: A metformin propionate is represented by chemical formula 1. A method for preparing the metformin propionate represented by chemical formula 1 comprises the steps of: reacting metformin hydrochloride represented by chemical formula 2 with base in an organic solvent to prepare metformin free base represented by chemical formula 3; and reacting the metformin free base with propionic acids.