PYRAZOLE COMPOUNDS FOR ROS KINASE INHIBITORS

摘要

PURPOSE: A novel pyrazole compound I provided to ensure excellent activity on ROS kinase enzyme and to suppress development of glioblastoma multiforma, CNS cancer, and brain cancer. CONSTITUTION: A pyrazole compound is denoted by chemical formula 1. A pharmaceutical composition for anti-cancer contains the pyrazole compound. An anticancer agent contains the pyrazole compound as an active ingredient. The anticancer agent is used for treating brain cancer, CNS caner, and glioblastoma multiforma. A method for preparing the pyrazole compound comprises: a step of reacting a hetero aromatic compound of chemical formula 3 with methyl 3-methoxy-5-methoxybenzoate compound of chemical formula 2 under the presence of lithium hexamethyldisilazide(LHMDS) to obtain a keto-enol tautomer compound; and a step of reacting the keto-enol tauotmer compound with hydrazine hydrate under anhydrous ethanol condition.