CRYSTAL OF BICALUTAMIDE AND PRODUCTION METHOD THEREOF

摘要

The invention relates to crystals of bicalutamide having a specific crystal form, and industrially practicable processes for the production of bicalutamide and crystals thereof which are excellent in environmental friendliness, economical efficiency, and safeness. The invention provides a process for the production of bicalutamide represented by formula (1): (1) characterized by comprising at least the step of reacting a compound represented by formula (3) with an oxidizing agent: (3) a process for the production of crystals of bicalutamide; and a crystal form of bicalutamide as determined by X-ray diffraction (XRD) or solid-state 13C NMR spectroscopy.