MARCADORES GENETICOS PARA EL PRONOSTICO DE LA ESCLEROSIS MULTIPLE.
摘要
The present invention relates to a series of genes the expression of which is altered in subjects suffering multiple sclerosis with respect to healthy subjects or in subjects suffering multiple sclerosis with a good prognosis with respect to subjects suffering multiple sclerosis with a bad prognosis. A subset formed by 13 genes and two clinical variables which allows predicting the progress of a patient with a high reliability has been validated from an initial set of genes which showed said differential expression. From said expression values, the invention provides methods for predicting the progress of a patient diagnosed with multiple sclerosis from tables of conditional probability between the expression levels of a determined gene or group of genes and the probability that the patient has a good or bad prognosis of the disease.
申请公布号
ES2334084(B1)
申请公布日期
2011.01.24
申请号
ES20070003415
申请日期
2007.12.21
申请人
INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A.;PROGENIKA BIOPHARMA, S.A.