发明名称 |
MATERIAL AND PROCESS FOR INCORPORATION OF LOW DOSAGE ACTIVE PHARMACEUTICAL INGREDIENTS AND USE THEREOF |
摘要 |
<p>A low dose API pharmaceutical tablet having excellent content uniformity is provided. The tablet is formed by spray coating a support excipient with the API. The resulting composition is suitable for direct compression tablet formulation without the need for an additional granulation step to uniformly coat the API onto the support excipient. The support excipient comprises microcrystalline cellulose, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the support excipient components.</p> |
申请公布号 |
WO2011008674(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
WO2010US41665 |
申请日期 |
2010.07.12 |
申请人 |
MALLINCKRODT BAKER, INC.;FARINA, JAMES;DEORKAR, NANDU;MIINEA, LILIANA |
发明人 |
FARINA, JAMES;DEORKAR, NANDU;MIINEA, LILIANA |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K31/19;A61K31/44;A61K31/5415 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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