A NOVEL THERAPEUTICALLY COMBINATION OF NICOTINIC ACID AND MELDONIUM

摘要

The present invention comprises a synergistic combination of nicotinic acid and meldonium characterized by increased efficiency in treating metabolic-related disorders, including dyslipidemia, hyperlipidemia, atherosclerosis, coronary heart disease as chosen from the group of angina pectoris and myocardial infarction, transient and permanent ischemic attack including cerebrovascular accident and stroke and peripheral arterial occlusive disease, and by reduced flushing effect and/or increase of blood glucose levels, comprising as active ingredients nicotinic acid or pharmaceutically acceptable salt thereof and meldonium or pharmaceutically acceptable salt thereof, effective for said purpose. Such combination comprises nicotinic acid or pharmaceutically acceptable salt thereof in dose at least about 50 - 500 mg and meldonium or pharmaceutically acceptable salt thereof in dose at least about 50 - 500 mg in a pharmaceutical composition form, comprising the active ingredients in association with a pharmaceutically acceptable diluent or carrier. Moreover, a method of treating metabolic-related disturbances in a subject in need of the same is provided, comprising the step of simultaneously or sequentially administering to the said subject both nicotinic acid and meldonium as separate pharmaceutical compositions, the first composition comprising about 50 - 500 mg of nicotinic acid or pharmaceutically acceptable salt thereof and the second composition comprising about 50 - 500 mg of meldonium or pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable diluent or carrier.