发明名称 |
Cancer Chemoprevention Strategy Based on Loss of Imprinting of IGF2 |
摘要 |
The present invention relates to targets of loss of imprinting (LOI) affected IGF2 gene products in pre-malignant tissues, where methods of inhibiting those targets, including IGFR1, are disclosed to prevent tumor development in subjects at risk for developing colorectal cancer (CRC). The present invention also relates to methods of identifying increased risk in developing CRC in a subject, including methods of assessing the efficacy of a chemotherapeutic regimen. Further, the present invention relates to methods for identifying anti-neoplastic agents.
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申请公布号 |
US2011014204(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
US20070446735 |
申请日期 |
2007.12.07 |
申请人 |
FEINBERG ANDREW P;LEVCHENKO ANDRE;LONGO DAN L;KO MINORU S H |
发明人 |
FEINBERG ANDREW P.;LEVCHENKO ANDRE;LONGO DAN L.;KO MINORU S.H. |
分类号 |
A61K39/395;A61K31/277;A61K31/343;A61K31/351;A61K31/357;A61K31/407;A61K31/4178;A61K31/475;A61K31/513;A61K31/517;A61K31/519;A61K31/52;A61K31/538;A61K31/551;A61K31/58;A61K31/655;A61K31/704;A61K31/7048;A61K31/7056;A61K31/706;A61K31/7068;A61K31/7072;A61K31/7076;A61K33/24;A61K38/08;A61P35/00;C12Q1/68;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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