METHOD FOR SCREENING OF AGENT FOR TREATING AND DIAGNOSING PRENATAL NEURONAL DISEASE IN MATERNAL EPILEPSY

摘要

PURPOSE: A method for screening a therapeutic agent for treating fetal dysneuria caused by maternal epilepsy during pregnancy is provided to develop the therapeutic agent. CONSTITUTION: A method for screening a therapeutic agent for treating dysneuria comprises: a step of detecting expression of GABA_B1 receptor and PK(protein kinase A) in a hippocampus neuron of an individual; a step of administering PTZ(pentylenetetrazol) or ethanol to the individual; a step of selecting an individual in which GABA_B1 receptor and PKA expression level is reduced; a step of administering a candidate material to the selected individual; and a step of confirming the increase of GABA_B1 receptor and PKA expression.