发明名称 |
USE OF NORGESTIMATE AS A SELECTIVE INHIBITOR OF TRPC3, TRPC6 AND TRPC7 ION CHANNELS |
摘要 |
TRPC ion channels are non-selective channels widely expressed in human tissues. These channels are involved in numerous physiological functions and are putative targets for the development of novel medicines. There is a need to gain a better understanding of TRPC ion channels in cells and beyond. The present invention provides a pharmacological tool compound that allows to study TRPC ion channels due to its discriminating inhibition of TRPC subfamilies. In the present invention, norgestimate is shown to selectively inhibit TRPC3, TRPC6 and TRPC7.
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申请公布号 |
US2011015167(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
US20080738137 |
申请日期 |
2008.10.14 |
申请人 |
SANOFI-AVENTIS |
发明人 |
MIEHE SUSANNE;KLEEMANN HEINZ-WERNER;STRUEBING CARSTEN |
分类号 |
A61K31/567;A61P9/10;A61P13/12;A61P25/00;C12N5/071;G01N33/567 |
主分类号 |
A61K31/567 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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