| 摘要 |
FIELD: medicine. ^ SUBSTANCE: described is a pharmaceutical composition containing Enhol peptide or its functional fragment, functional homolog or functional structural analogue with conservative amino acid substitutes, and a pharmaceutically acceptable carrier for treatment and prevention of a pathophysiological state associated with excessive body weight. Offered are methods of treating and preventing the pathophysiological state referred to body weight homeostasis, including the introduction to an individual of a therapeutically effective amount of the described pharmaceutical composition. Presented are methods for improving or reducing insulin resistance in an individual, relieving or treating diabetes symptoms in an individual, preventing or delaying obesity in an individual, including the introduction to an individual of a therapeutically effective amount of Enhol peptide or its functional fragment, functional homolog or functional structural analogue with conservative amino acid substitutes. ^ EFFECT: invention can be used as a therapeutic or diagnostic modalities in hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes or energy imbalance. ^ 11 cl, 23 dwg, 3 tbl, 25 ex |
