发明名称 |
Use of low-molecular-weight highly sulfated polysaccharide derivatives for modulating angiogenesis |
摘要 |
<p>The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10μg (m) g/ml.</p> |
申请公布号 |
AU2005259077(B2) |
申请公布日期 |
2011.01.20 |
申请号 |
AU20050259077 |
申请日期 |
2005.06.06 |
申请人 |
UNIVERSITE RENE DESCARTES PARIS 5;INSTITUT FRANCAIS DE RESCHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER) |
发明人 |
CORINNE SINQUIN;DOMINIQUE HELLEY;JACQUELINE RATISKOL;SABINE MATOU;CLAIRE BOISSET;ANNE-MARIE FISCHER;SYLVIA COLLIEC-JOUAULT;JEAN GUEZENNEC |
分类号 |
A61K31/737;A61P9/10;A61P17/02;A61P19/02;A61P35/00 |
主分类号 |
A61K31/737 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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