发明名称 |
HIGH AFFINITY NY-ESO T CELL RECEPTORS |
摘要 |
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
|
申请公布号 |
US2011014169(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
US20100854691 |
申请日期 |
2010.08.11 |
申请人 |
IMMUNOCORE LIMITED |
发明人 |
BOULTER JONATHAN MICHAEL;JAKOBSEN BENT KARSTEN;LI YI;MOLLOY PETER EAMON;DUNN STEVEN MARK;BOULTER LUCY |
分类号 |
A61K35/12;A61K38/00;A61P35/00;C07K14/705;C07K14/725;C12N5/07 |
主分类号 |
A61K35/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|