发明名称 |
PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE |
摘要 |
Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier. |
申请公布号 |
CA2770980(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
CA20102770980 |
申请日期 |
2010.07.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
TSIEN, ROGER;AGUILERA, TODD;OLSON, EMILIA;JIANG, TAO;NGUYEN, QUYEN |
分类号 |
C07K7/06;A61K47/42;A61K49/00;C07K7/08;G01N33/52;G01N33/68 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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