发明名称 |
Production of 1,4 Butanediol in a Microorganism |
摘要 |
A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline; (d) conversion of 5-hydroxy-L-norvaline to 5-hydroxy-2-oxopentanoate; (e) conversion of 5-hydroxy-2-oxopentanoate to 4-hydroxybutanal; and (f) the conversion of 4-hydroxybutanal to 1,4-butanediol.
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申请公布号 |
US2011014669(A1) |
申请公布日期 |
2011.01.20 |
申请号 |
US20100692943 |
申请日期 |
2010.01.25 |
申请人 |
MICROBIA, INC.;TATE & LYLE INGREDIENTS AMERICAS, INC. |
发明人 |
MADDEN KEVIN T.;YOUNG DAVID M.;BOWER STANLEY;LIU CHI-LI |
分类号 |
C12P7/18;C12N1/00;C12N1/21 |
主分类号 |
C12P7/18 |
代理机构 |
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地址 |
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