摘要 |
A process for stereoselective synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromelhyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; R2 and R3 are each independendy C1-C5 alkyl; R is C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C1- C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C1-C5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone. |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;FANDRICK, DANIEL ROBERT;REEVES, JONATHAN TIMOTHY;SONG, JINHUA J.;TAN, ZHULIN;QU, BO;YEE, NATHAN;RODRIGUEZ, SONIA |
发明人 |
FANDRICK, DANIEL ROBERT;REEVES, JONATHAN TIMOTHY;SONG, JINHUA J.;TAN, ZHULIN;QU, BO;YEE, NATHAN;RODRIGUEZ, SONIA |