发明名称 |
PRODUKTION VON IGM DURCH TRANSFORMIERTE ZELLEN UND VERFAHREN ZUR QUANTIFIZIERUNG DIESER IGM-PRODUKTION |
摘要 |
IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM. |
申请公布号 |
DE602004030451(D1) |
申请公布日期 |
2011.01.20 |
申请号 |
DE20046030451T |
申请日期 |
2004.07.15 |
申请人 |
CHUGAI SEIYAKU K.K. |
发明人 |
IRIE, REIKO;TSUNODA, HIROYUKI;IGAWA, TOMOYUKI;SEKIMORI, YASUO;TSUCHIYA, MASAYUKI |
分类号 |
C12N15/13;C07K16/00;C07K16/18;C07K16/30;C12N5/10;C12P21/02;G01N27/447;G01N33/53;G01N33/561;G01N33/68 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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