| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: it is proposed to use 3,11b-cis-dihydrotetrabenazine (earlier available for treatment of hyperkinesis) or its pharmaceutically acceptable salt for production of medical agent to prevent or treat inflammatory disease and according method of prophylactics (treatment). It is demonstrated that all stereoisomers of 3,11b-cis-dihydrotetrabenazine are linked to sigma-1- and sigma-2-receptors, modulate production of cytokines by human monocytes, in high concentrations suppress proliferation of T-cells (T-cells are regulators of inflammation in case of a wide range of diseases). In particular, isomer D reduced production of IL-2, IL-4, IL-5, IL-10, IL-12, TNF-. ^ EFFECT: production of pharmaceutical composition for production of medicinal agent for prophylactics or treatment of inflammatory disease. ^ 13 cl, 6 dwg, 14 tbl, 9 ex |
