| 摘要 |
<p>A topical formulation comprising: (a) an NSAID or a pharmaceutically acceptable salt thereof; (b) a polyhydric alcohol; (c) a C10—C14straight chain fatty acid or derivative thereof; (d) a C2- C4alcohol; (e) a gelling agent selected from the group consisting of non-ionic polymers; (f) optionally additional pharmaceutically acceptable excipients; (g) water up to 100%. The NSAID is selected from ibuprofen, ketoprofen, flurbiprofen, diclofenac, or naproxen, and is preferably ibuprofen. The polyhydric alcohol is preferably propylene glycol or butylene glycol. The fatty acid is preferably lauric acid or myristic acid. The C2—C4alcohol is preferably isopropanol. The gelling agent is preferably hydroxypropyl cellulose, hydroxylethyl cellulose, or a polyacrylamide. The topical formulation may further comprise an ingredient that stimulates cold or warm receptors in the skin, preferably menthol or capsaicin. The formulation may comprise up to 10% menthol. The topic formulations may further comprise an additional analgesic agent.</p> |
