Pharmaceutical metered dose inhaler and methods relating thereto

摘要

Methods of preparing elastomeric gasket materials for use in metered dose inhalers that include contacting an elastomeric gasket material to be used in a metered dose inhaler, which gasket material comprises one or more extractable compounds, with a solution comprising an organic solvent under conditions sufficient to extract at least a portion of at least one of the one or more extractable compounds from the elastomeric gasket material are described. Sealing gaskets made by such methods as well as metering valves, metered dose inhalers, and drug products that include such gaskets are also described.