发明名称 |
Compositions and their uses directed to hepcidin |
摘要 |
<p>Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or treating anemia. Also provided are methods for prevention, amelioration or treatment of anemia, and for increasing red blood cell count in an animal. Also provided are methods for the prevention, amelioration and/or treatment of low serum iron levels, low red blood cell count and other clinical endpoints of anemia in an animal. These methods may be achieved by administration of compounds or compositions including antisense compounds targeted to a nucleic acid that expresses hepcidin polypeptide combined with an crythropoiesis stimulating agent.</p> |
申请公布号 |
EP2275543(A2) |
申请公布日期 |
2011.01.19 |
申请号 |
EP20100177775 |
申请日期 |
2007.04.12 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MONIA, BRETT P.;BENNETT, C. FRANK;GAARDE, WILLIAM A.;LOCKHART, TRISHA;MCKAY, ROBERT |
分类号 |
A61K31/00;C12N15/113 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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