BIFUNCTIONAL BIS-CINCHONA ALKALOID THIOUREA ORGANO CATALYSTS, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING CHIRAL AMINO ACID FROM AZLACTONES USING THE SAME

摘要

PURPOSE: A bifunctional bis-cinchona alkaloid thiourea organic chiral catalyst compound and a method for preparing the same are provided to obtain (R)-type N-acyl amino acid ester of highly optical purity. CONSTITUTION: A bifunctional bis-cinchona alkaloid thiourea organic chiral catalyst compound is denoted by chemical formula 1. In chemical formula 1, R is ethyl group or -CH=CH_2. The bifunctional organic chiral catalyst is obtained by reacting amine with carbothio diimidazole. The amine is obtained from cinchona alkaloid by epimerization. A chiral N-acyl amino acid ester is obtained by reacting N-acyl amino acid, racemic azlactone, (S)-azlactone or (R)-azlactone with neucleophile under the presence of bifunctional chiral organic catalyst. The neucleophile is alcohol or thiol.