发明名称 |
High frequency of neurexin 1&bgr; signal peptide structural variants in patients with autism |
摘要 |
The three &bgr;-neurexins have similar roles in synaptogenesis and interact with the neuroligins. Mutations located within the gene encoding neurexin 1 have been identified as molecular markers associated with autism and autism-related disorders. The estimated attributable risk is 2%. The invention provides methods of diagnosing or predicting susceptibility to developing autism in an individual by determining the presence or absence of one or more genetic variant of a neurexin 1 gene in an individual.
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申请公布号 |
US7871820(B2) |
申请公布日期 |
2011.01.18 |
申请号 |
US20070859631 |
申请日期 |
2007.09.21 |
申请人 |
CITY OF HOPE |
发明人 |
SOMMER STEVE S.;FENG JINONG;YAN JIN |
分类号 |
C12P19/34 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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