发明名称 |
Process for the removal of exocyclic base protecting groups |
摘要 |
Nitrogen-protecting groups are removed from the exocyclic nucleobase portion of a 2′-O protected nucleotide or 2′-halo nucleotide by contacting the nucleotide with an inorganic base. Typical is the removal of t-butylphenoxyacetyl protecting groups from the nucleobase portion of a 2′-O protected nucleotide on which the 2′-O protecting group is t-butyldimethylsilyl, removal or deprotection being accomplished by contact with a potassium carbonate solution.
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申请公布号 |
US7872121(B2) |
申请公布日期 |
2011.01.18 |
申请号 |
US20050578961 |
申请日期 |
2005.04.15 |
申请人 |
AVECIA BIOTECHNOLOGY, INC. |
发明人 |
SINHA NANDA DULAL;KUCHIMANCHI SATYA |
分类号 |
C07H21/00 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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