Blood coagulation time determination method and apparatus

摘要

The invention relates to a method for determining the coagulation time of a sample fluid containing blood components by means of a resonator whose vibration parameters are measured and then used as a basis for determining the sample fluid viscosity change, which resonator has an at least partially adhesive surface contacting said sample fluid. The invention is characterized by preincubation of said surface with a preincubation fluid containing blood components, which preincubation fluid has a known way of interacting with the coagulation system, thus resulting in anchoring sites to be formed on the adhesive areas of said surface.

主权项

1. An apparatus for determining the coagulation time of a sample fluid containing blood components, comprising: a resonator, said resonator includes a surface, said surface of said resonator is a vibrating quartz crystal surface, said vibrating quartz crystal surface of said resonator includes non-adhesive areas (22) and adhesive areas (24) arranged in a mosaic on said vibrating quartz crystal surface, preincubation fluid containing blood components, said preincubation fluid (14) forming anchoring sites on said adhesive areas on said vibrating quartz crystal surface of said resonator, said adhesive areas of said vibrating quartz crystal surface of said resonator are adhesive with respect to said blood components of said sample fluid and said non-adhesive areas (22) of said vibrating quartz crystal surface of said resonator are non-adhesive with respect to aid blood components of said sample fluid, said vibrating quartz crystal surface of said resonator has a resonant frequency dependent on said sample fluid which engages and anchors to said anchoring sites on said adhesive areas of said vibrating quartz crystal surface of said resonator, and, said coagulation time occurs when said resonant frequency of said vibrating quartz crystal surface is at a maximum.