| 摘要 |
The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof;
wherein R2, R3, R4, R6, R7, R8, R51 and R52 have the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases. |
| 主权项 |
1. A compound of the formula (I) or a salt thereof: wherein Y is N or CR1, R1, R3, and R4 are the same as or different from each other and are each H, halogen, or lower alkyl which may be substituted with one or more substituents selected from the group consisting of halogen, —OH, —O-lower alkyl, —O-halogeno-lower alkyl and —NR9R10, R2 is lower alkyl which may be substituted with one or more substituents selected from the group consisting of halogen and cyano, and R2 may be combined with R1 to form —(CH2)n—, or R2 may be combined with R3 to form —(CH2)n—, n is 2 or 3, R51 and R52 are the same as or different from each other and are each H, lower alkyl which may be substituted with one or more substituents selected from Group G2, or cycloalkyl which may be substituted with one or more substituents selected from Group G1, and further, R51 and R52 may be combined with a nitrogen atom to which they are bonded to form cyclic amino which may be substituted with one or more substituents selected from Group G1, X is a bond, —NR11—, or —NR11—O—, R11 is H or lower alkyl, R6 is lower alkyl which may be substituted with one or more substituents selected from Group G4, or cycloalkyl which may be substituted with one or more substituents selected from Group G3, further, when —X—R6— is NR11—R6, R6 and R11 may be combined with a nitrogen atom to which they are bonded to form cyclic amino which may be substituted with one or more substituents selected from Group G3, R7 and R8 are the same as or different from each other and are each H or lower alkyl which may be substituted with one or more substituents selected from the group consisting of halogen, —OH, and —O-halogeno-lower alkyl, Group G1 and Group G3 are lower alkyl, halogeno-lower alkyl, halogen, —OH, —O-lower alkyl, —O-halogeno-lower alkyl, and —NR9R10, Group G2 and Group G4 are halogen, —OH, —O-lower alkyl, —O-halogeno-lower alkyl, cycloalkyl which may be substituted with one or more halogen atoms, —O-(cycloalkyl which may be substituted with one or more halogen atoms), and —NR9R10, and R9 and R10 are the same as or different from each other and are H or lower alkyl). |
