(AZA-)isoquinolinone derivatives

摘要

Compounds of the formula I;
in which R1, X, Y and n have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

主权项

1. A compound which isNo.Name“A3”3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-2H-isoquinolin-1-one“A5”6-fluoro-3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-2H-isoquinolin-1-one“A6”7-fluoro-3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-2H-isoquinolin-1-one“A7”3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-7-methyl-2H-isoquinolin-1-one“A8”3-(4-hydroxymethyl-phenyl)-2H-isoquinolin-1-one“A16”7-fluoro-3-{4-[1-(2-hydroxy-ethoxy)-1-methyl-ethyl]-phenyl}-2H-isoquinolin-1-one“A20”3-[4-(1-amino-1-methyl-ethyl)phenyl]-7-fluoro-2H-isoquinolin-1-one“A23”3-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2H-2,6-naphthyridin-1-one“A24”3-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2H-2,7-naphthyridin-1-one“A25”7-chloro-3-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2H-isoquinolin-1-one“A26”3-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-5-methoxy-2H-isoquinolin-1-one“A27”8-fluoro-3-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2H-isoquinolin-1-one“A28”5-fluoro-3-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2H-isoquinolin-1-oneor“A33”5,7-difluoro-3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-2H-isoquinolin-1-oneor a pharmaceutically acceptable solvate, salt, tautomer or stereoisomer thereof, or a mixture thereof in all ratios.