| 发明名称 |
DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS |
| 摘要 |
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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| 申请公布号 |
US2011009409(A1) |
申请公布日期 |
2011.01.13 |
| 申请号 |
US20100829667 |
申请日期 |
2010.07.02 |
| 申请人 |
BLAIR BROOKE;FATHEREE PAUL R;FLEURY MELISSA;GENDRON ROLAND;HUDSON RYAN;MCKINNELL ROBERT MURRAY;WILSON MICHAEL |
发明人 |
BLAIR BROOKE;FATHEREE PAUL R.;FLEURY MELISSA;GENDRON ROLAND;HUDSON RYAN;MCKINNELL ROBERT MURRAY;WILSON MICHAEL |
| 分类号 |
A61K31/5377;A61K31/41;A61K31/415;A61K31/422;A61K31/4439;A61K31/497;A61P3/06;A61P3/10;A61P7/02;A61P9/12;A61P13/12;A61P29/00;C07D231/20;C07D257/04;C07D401/12;C07D403/14;C07D413/12 |
主分类号 |
A61K31/5377 |
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