| 摘要 |
The present invention relates to a marker for diagnosis of fungal infections, which is sequentially activated in vivo in the presence of ß-1,3-glucan, which activates the Toll signaling pathway, to compositions for diagnosis of fungal infections in a specimen, and to a method for producing antibacterial substances. More particularly, the present invention has proved that a GNBP3-mediated ß-1,3-glucan recognition signal reaches pro-Spaetzle using three serine proteases as mediators, namely, modular serine protease (MSP), Spaetzle-processing enzyme activating enzyme (SAE), and Spaetzle-processing enzyme (SPE). Proteins involved with ß-1,3-glucan recognition signaling can be effectively used as compositions for detecting fungal infections in blood samples or the like. |
