METHOD FOR PREVENTING AND TREATING CANCER METASTASIS AND BONE LOSS ASSOCIATED WITH CANCER METASTASIS

摘要

PROBLEM TO BE SOLVED: To identify new agents and methods for preventing or treating cancer metastasis, including osteolytic bone metastases.SOLUTION: The present invention provides an M-CSF antagonist, a pharmaceutical composition comprising the M-CSF antagonist, a kit comprising the pharmaceutical composition, a method for preventing and treating bone metastases in a subject afflicted with metastasis cancer, a method of screening for an M-CSF antagonist and a pharmaceutical, and the use of an M-CSF in the manufacture of a medicament for preventing and treating bone metastases and tumor growth. It is contemplated that the methods achieve their therapeutic potential by inhibiting the interaction between M-CSF and its receptor (M-CSFR). It is further contemplated that the inhibition of M-CSF/M-CSFR interaction inhibits osteoclast proliferation and/or differentiation induced by tumor cells.