HISTONE DEACETYLASE INHIBITORS WITH BRANCHED STRUCTURE SYNTHESIZED THROUGH CLICK CHEMISTRY

摘要

Histone deacetylase inhibitors with branched structure synthesized through click chemistry are disclosed. The inhibitors are represented by formula M1, wherein A is a C1-C6 alkyl chain, R1 and R2 are alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, heteroalkenyl, heterocycloalkenyl, alkynyl, cycloalkynyl, heteroalkynyl, heterocycloalkynyl, aryl or heteroaryl, R1 and R2 can be same or different. Compounds obtained by substituted or bridged modifying A, R1 and/or R2 of the above inhibitors are also included. In addition, the said histone deacetylase inhibitors can also be used for preparing medicaments for treating cardiovascular diseases, immune diseases and neurodegenerative diseases.