发明名称 |
SYSTEM FOR DELIVERY OF PROTEIN IN INSOLUBLE FIBRILLAR OR AGGREGATE FORM |
摘要 |
A pharmaceutical composition containing a therapeutic protein which is particularly amenable to oral administration by providing stability in the gastrointestinal tract. Insoluble fibrils or aggregates of the therapeutic protein in the pharmaceutical composition are encapsulated in a lipidated glycosaminoglycan particle, coated with a multi-layer of lipids and lipid-glycosaminoglycan conjugates, or present as unencapsulated and uncoated insoluble fibrils or aggregates.
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申请公布号 |
US2011008422(A1) |
申请公布日期 |
2011.01.13 |
申请号 |
US20090920096 |
申请日期 |
2009.02.18 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD. |
发明人 |
DEKEL YARON;MARGALIT RIMONA |
分类号 |
A61K9/127;A61K9/14;A61K38/28;A61P3/10 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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