发明名称 |
SPECIFIC GRP78 EXPRESSION-INHIBITION RNAi SEQUENCE, MEDICINE THEREOF AND METHOD THEREOF |
摘要 |
The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5′-AAGGATGGTTAATGATGCTGAGAA-3′ [SEQ. ID NO: 1] complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
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申请公布号 |
US2011008882(A1) |
申请公布日期 |
2011.01.13 |
申请号 |
US20090433183 |
申请日期 |
2009.04.30 |
申请人 |
CHENG ANN-JOY;CHANG JOSEPH T;CHIU CHING-CHI |
发明人 |
CHENG ANN-JOY;CHANG JOSEPH T.;CHIU CHING-CHI |
分类号 |
C12N15/63;C07H21/02;C12N15/113 |
主分类号 |
C12N15/63 |
代理机构 |
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地址 |
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