发明名称 |
INHIBITORS OF PROTEIN KINASES |
摘要 |
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. |
申请公布号 |
EP2271631(A2) |
申请公布日期 |
2011.01.12 |
申请号 |
EP20090734422 |
申请日期 |
2009.04.22 |
申请人 |
PORTOLA PHARMACEUTICALS, INC. |
发明人 |
SONG, YONGHONG;XU, QING;BAUER, SHAWN, M.;JIA, ZHAOZHONG, J.;MEHROTRA, MUKUND;PANDEY, ANJALI |
分类号 |
C07D239/48;A61K31/506;A61K31/52;A61P9/00;A61P29/00;A61P35/00;C07D401/04;C07D401/14;C07D403/04;C07D471/04;C07D473/16 |
主分类号 |
C07D239/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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