发明名称 |
TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF |
摘要 |
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation. |
申请公布号 |
KR20110003523(A) |
申请公布日期 |
2011.01.12 |
申请号 |
KR20107024935 |
申请日期 |
2009.04.08 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
GIN DAVID;ADAMS MICHELLE;DENG KAI;PERL NICHOLAS;WON ANNIE;LIVINGSTON PHILIP;RAGUPATHI GOVIND |
分类号 |
C07H15/24;A61K31/56;A61K31/704;A61P37/04 |
主分类号 |
C07H15/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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