4-(BENZYLIDENEAMINO)-3-(METHYLSULFANYL)-4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES HAVING A PDE IV-INHIBITING AND TNF-ANTAGONISTIC ACTION FOR THE TREATMENT OF HEART DISEASES AND ALLERGIES

摘要

The invention relates to triazine derivatives of formula (I), and the physiologically compatible salts and solvates thereof, wherein R1, R2, A and R5 have the designations cited in claim 1. Said derivatives exhibit a phosphodiesterase IV-inhibiting action and can be used for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, pancreatic diabetes or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory defects, arteriosclerosis and AIDS. Said derivatives can also be used to inhibit the formation of TNF .alpha..