发明名称 |
Recombinant human interferon-like proteins |
摘要 |
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.
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申请公布号 |
US7868151(B2) |
申请公布日期 |
2011.01.11 |
申请号 |
US20090555762 |
申请日期 |
2009.09.08 |
申请人 |
NOVAGEN HOLDING CORPORATION |
发明人 |
WANG HAITAO;MAO CHUNSHENG;LI JIZHI;XU JING;ZHANG RUI;WANG LING;DU YONG;LIU LONGBIN |
分类号 |
C07H21/04;A61K38/15;C07K14/00;C12P21/02 |
主分类号 |
C07H21/04 |
代理机构 |
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