COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES

摘要

The present invention provides a process of catalyzing a click chemistry ligation reaction between a first reactant having a terminal alkyne moiety and second reactant having an azide moiety for forming a product having a triazole moiety, the click chemistry ligation reaction being performed in a solution in contact with metallic copper, said metallic copper contributing directly or indirectly to the catalysis of the click chemistry ligation reaction.