发明名称 |
SINGLE STRANDED EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION |
摘要 |
The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs.
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申请公布号 |
US2011003881(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
US20100824011 |
申请日期 |
2010.06.25 |
申请人 |
DICERNA PHARMACEUTICALS, INC. |
发明人 |
BROWN BOB D. |
分类号 |
A61K31/713;A61P35/00;C07H21/00;C12N5/07;C12P19/34 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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