发明名称 |
SYNTHESIS OF N4- (2, 2-DIMETHYL-4- [ (DIHYDROGEN PHOSPHONOXY)METHYL]-3-OXO-5-PYRIDO [1, 4]OXAZIN-6-YL)-5-FLUORO-N2-(3,4, 5-TRIMETHOXYPHENYL)-2, 4-PYRIMIDINEDIAMINE DISODIUM SALT |
摘要 |
This invention relates to the field of pharmaceutical/process chemistry. Disclosed herein is a process for preparing N4- (2, 2-dimethyl-4- [ (dihydrogen phosphonoxy) methyl] -3-oxo-5-pyrido [1,4] oxazin-6-yl) -5~fluoro-N2- (3,4, 5-trimethox yphenyl) -2, 4-pyrimidinediamine disodium salt, particularly hydrates (such as a hexahydrate). The compound is useful in the treatment and prevention of various diseases. Also disclosed is a process of preparing N4- (2, 2-dimethyl-4- [ (dialkyl phosphonoxy) methyl] -3-oxo-5-pyrido [1, 4] oxazin-6-yl) -5-f luoro-N2- (3,4, 5-trimethox yphenyl ) -2, 4-pyrimidinediamine. Both processes involve the use of an amide. in.
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申请公布号 |
CA2766801(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
CA20102766801 |
申请日期 |
2010.07.01 |
申请人 |
RIGEL PHARMACEUTICALS, INC. |
发明人 |
FELFER, ULFRIED;GISELBRECHT, KARL-HEINZ;WOLBERG, MICHAEL |
分类号 |
C07F9/6561 |
主分类号 |
C07F9/6561 |
代理机构 |
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代理人 |
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地址 |
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