发明名称 |
Fc receptor modulating compounds and compositions |
摘要 |
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor. |
申请公布号 |
AU2010249262(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
AU20100249262 |
申请日期 |
2010.12.09 |
申请人 |
THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTD |
发明人 |
PHILLIP MARK HOGARTH;GEOFFREY ALLAN PIETERSZ;GERARD PETER MOLONEY |
分类号 |
A61P37/00;A61K31/12;A61K31/165;A61K31/192;A61K31/381;A61K31/41;A61K31/4166;C07C57/42;C07C59/68;C07C63/66;C07C65/38;C07C69/618;C07C229/60;C07C233/05;C07C233/11;C07C251/24;C07C251/86;C07C255/41;C07C271/22;C07C275/24;C07C275/42;C07C317/44;C07C323/22;C07C323/56;C07C323/60;C07C323/62;C07C323/63;C07D207/32;C07D207/333;C07D249/14;C07D277/20;C07D277/36;C07D303/38;C07D333/70;C07D409/12;C07D409/14;C07K5/06;C07K5/083 |
主分类号 |
A61P37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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