发明名称 |
COMPOSITIONS AND METHODS FOR OSTEOGENIC GENE THERAPY |
摘要 |
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
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申请公布号 |
US2011004947(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
US20100879842 |
申请日期 |
2010.09.10 |
申请人 |
THE UNITED STATES GOVERNMENT, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
LAU KIN-HING WILLIAM;BAYLINK DAVID J.;HALL SUSAN L.;CHEN SHIN-TAI;MOHAN SUBBURAMAN |
分类号 |
A01K67/00;C07H21/04;C12N5/071;C12N5/0783;C12N15/00;G01N33/53 |
主分类号 |
A01K67/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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