FORMULATIONS

摘要

Anti-acne formulation containing (i) 3.5% w/v or greater of a dialkyl sulpho succinate (DAS) such as a dioctyl sulpho succinate and (ii) salicylic acid or a derivative thereof (other than a halogenated salicylanilide), which is suitable for application as a topical leave-on formulation. The salicylic acid or derivative may be present at a concentration of 0.5% w/w. The formulation may contain, in addition to the DAS and the salicylic acid or derivative, (a) a polyoxyalkylene-based solubilising agent and (b) an organic solvent, in particular an alcohol, optionally together with a thickening agent and/or water. It may contain an antioxidant such as AO 2246 or AO 425. It may be applied once daily over a period of several weeks.