发明名称 |
CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME |
摘要 |
A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.
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申请公布号 |
US2011003315(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
US20070300148 |
申请日期 |
2007.05.08 |
申请人 |
INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL |
发明人 |
SEIDAH NABIL G.;DAVIGNON JEAN;DUBUC GENEVIEVE;BERNIER LISE;TREMBLAY MICHEL |
分类号 |
G01N33/567;C12N5/10;C12N9/50;C12Q1/37 |
主分类号 |
G01N33/567 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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