发明名称 |
NEUROTOXINS EXHIBITING SHORTENED BIOLOGICAL ACTIVITY |
摘要 |
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a Neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises a at least one degradation signal in the light chain as well as vectors and host cells comprising the said polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising said polynucleotides and polypeptides as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments. |
申请公布号 |
WO2011000929(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
WO2010EP59398 |
申请日期 |
2010.07.01 |
申请人 |
MERZ PHARMA GMBH & CO. KGAA;HOFMANN, FRED;FREVERT, JUERGEN |
发明人 |
HOFMANN, FRED;FREVERT, JUERGEN |
分类号 |
C12N9/52;A61K31/713;A61K38/48;C07K14/33;C07K16/12;C12N1/21;C12N15/63;C12P21/02 |
主分类号 |
C12N9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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